Ryan L Minster

  • Assistant Professor, Human Genetics

Dr Minster is a genetic epidemiologist who focuses on the genetics of complex traits such as body composition, obesity and healthy aging. He is particularly interested in pleiotropic relationships among complex phenotypes such as those between bone mineral density and geometry, lean muscle mass and fat mass. He is also interested in evidence of selection in population isolates and their impact on human disease.


1998 | University of Pittsburgh, Pittsburgh, PA | Bachelor of Science, Molecular Biology
2003 | University of Pittsburgh, Pittsburgh, PA | Master of Science in Information Science
2011 | University of Pittsburgh, Pittsburgh, PA | Doctor of Philosophy, Human Genetics



Genomic Data Processing & Structures | HUGEN 2071
Genomic Data Pipelines & Tools | HUGEN 2072
Genomic Data Visualization & Integration | HUGEN 2073
Genome Bioinformatics Capstone | HUGEN 2074


Bioinformatics Resources for Geneticists | HUGEN 2010
Bioinformatics for Human Genetics | HUGEN 2070
Statistical Genetics | HUGEN 2080

Selected Publications

J.C. Carlson, D.E. Weeks, N.L. Hawley, G. Sun, H. Chen, T. Naseri, M.S. Reupena, R. Deka, S.T. McGarvey &amp R.L. Minster. Genome-wide association studies in Samoans give insight into the genetic etiology of fasting serum lipid levels. bioR?iv.

M. Krishnan, T.J. Major, R.K. Topless, O. Dewes, L. Yu, J.M.D. Thompson, L. McCowan, J. deZoysa, L.K. Stamp, N. Dalbeth, J. Harre � Hindmarsh, N. Rapana, R. Deka, W.W.H. Eng, D.E. Weeks,R.L. Minster, S.T. McGarvey, S. Viali, P. Wilcox, D. Grattan, P.R. Shepherd, A.N. Shelling, R. Murphy &amp T.R. Merriman. Discordant association of the crebrf rs373863828 minor allele with increased body mass index and protection from type 2 diabetes in Maori and Pacific (Polynesian) people living in New Zealand. Diabetologia 61, 1603 (2018).

A.T. Kraja, E.W. Daw, P. Lenzini, L. Wang, S.J. Lin, C.A. Williams, A.B. Wells, K.L. Lunetta, J.M. Murabito, P. Sebastiani, G. Tosto, S. Barral, R.L. Minster, A. Yashin, T. Perls &amp M.A. Province.A comparison of genetic imputation methods using Long Life Family Study genotypes and sequence data with the 1000 Genome reference panel. Int. J. Bioinform. Res. Appl. in press.

M.M. Marron, J. Singh, R.M. Boudreau, K. Christensen, S. Cosentino, M.F. Feitosa,R.L. Minster, T. Perls, N. Schupf, P. Sebastiani, S. Ukraintseva, M.K. Wojczynski &amp A.B. Newman. A novel healthy blood pressure phenotype in the Long Life Family Study. J. Hypertens. 36, 43 (2018).
DOI: 10.1097/hjh.0000000000001514

S.A. Sherman, R.J. Rogers, K.K. Davis,R.L. Minster, S.A. Creasy, N.C. Mullarkey, M. O’Dell, P. Donahue, J.M. Jakicic. Energy expenditure in vinyasa yoga versus walking. J. Phys. Act. Health19, 1–29 (2017).
DOI: 10.1123/jpah.2016-0548

J. Singh,R.L. Minster, N. Schupf, A. Kraja, Y. Liu, L. Christensen, A.B. Newman, C.M. Kammerer. Genomewide association scan of a mortality associated endophenotype for a long and healthy life in the Long Life Family Study. J. Gerontol. A Biol. Sci. Med. Sci. in press.
DOI: 10.1093/gerona/glx011


R.L. Minster, N.L. Hawley, C.-T. Su, G. Sun, E.E. Kershaw, H. Cheng, O.D. Buhule, J. Lin, M.S. Reupena, S. Viali, J. Tuitele, T. Naseri, Z. Urban, R. Deka, D.E. Weeks, S.T. McGarvey. A thrifty variant inCREBRF strongly influences body mass index in Samoans. Nat. Genet.48, 1049–54 (2016).
DOI: 10.1038/ng.3620

J.L. Sanders, J. Singh,R.L. Minster, J.D. Walston, A.M. Matteini, K. Christensen, R. Mayeux, I.B. Borecki, T. Perls, A.B. Newman. Association Between Mortality and Heritability of the Scale of Aging Vigor in Epidemiology. J. Am. Geriatr. Soc.64, 1679–83 (2016).
DOI: 10.1111/jgs.14190

R.L. Minster, J.L. Sanders, J. Singh, C.M. Kammerer, M.M. Barmada, A.M. Matteini, Q. Zhang, M.K. Wojczynski, E.W. Daw, J.A. Brody, A.M. Arnold, K.L. Lunetta, J.M. Murabito, K. Christensen, T.T. Perls, M.A. Province, & A.B. Newman.Genome-Wide Association Study and Linkage Analysis of the Healthy Aging Index. J. Gerontol. A Biol. Sci. Med. Sci.70, 1003–8 (2015).
DOI: 10.1093/gerona/glv006

B.A. Kozel, C.-T. Su, J.R. Danback,R.L. Minster, S. Madan-Khetarpal, J. McConnell, M.K. Mac Neal, K.L. Levine, R.C. Wilson, R.C. Sciurba & Z. Urban.Biomechanical properties of the skin in cutis laxa.J. Invest. Dermatol.134, 2836–8 (2014).
DOI: 10.1038/jid.2014.224


O.D. Buhule, R.L. Minster, N.L. Hawley, M. Medvedovic, G. Sun, S. Viali, R. Deka, S.T. McGarvey, D.E. Weeks. Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale.Front. Genet. 5, 354 (2014).
DOI: 10.3389/fgene.2014.00354

N.L. Hawley,R.L. Minster, D.E. Weeks, S. Viali, M.S. Reupena, G. Sun, H. Cheng, R. Deka & S.T. McGarvey.Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan Genome-Wide Association Study.Am. J. Hum. Biol.26, 491–501 (2014).
DOI: 10.1002/ajhb.22553