Caterina Rosano

  • Professor and Vice Chair for Research
  • Associate Director for Clinical Translation, Aging Institute
  • Faculty in Epidemiology

I am a physician-scientist specializing in Population Neuroscience of Aging. I am especially interested in the neurobiological drivers of successful aging.

Why am I excited about brain aging? Although older age is typically associated with a seemingly inevitable performance decline, we have evidence that some older adults appear resistant and resilient to the effect of aging. Based on our discoveries, we believe that there are distinct neurobiological characteristics that can explain why some people age better than others and why some people respond to treatment better than others. We also believe that enhancing these neurobiological drivers of resilience can enhance function.

Why population neuroscience? The combination of neuroscience and population science is critical to capture the complex relationships between the heterogeneity of the individuals on the manifestations of the disease. Our work leverages the most recent methodologies of CNS assessment to “virtually” dissect the brain in vivo using very powerful and novel magnet resonance imaging. Our research inquiries are conducted in the context of carefully designed epidemiological studies.

What did we discover? We find that the “neurobiological drivers of resilience” appear related to microstructural integrity of brain connections, small vessel and dopaminergic signaling.

Why is this important? These findings are very important, because such resilience factors are modifiable. For example, we have shown that lower and stable levels of inflammatory markers and blood pressure are critically important for preservation of brain integrity in older age.

Questions? Information on our work and that of our trainees can be found at You can also reach me @crosanoeBrain or






Scientific Lycee, B. Croce, Palermo, Italy





University of Palermo Medical School, Palermo, Italy










University of Miami School of Medicine, Miami, FL

Foreign Exchange Program

The Miami Project to Cure Paralysis, Lois Pope Foundation; Neuroregenerative potential of white matter


Policlinico, University of Palermo Medical School, Palermo, Italy


Internal Medicine and Emergency Medicine

2001- 2003

Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA


Anne B. Newman, M.D., M.P.H

Epidemiology of Aging



Alzheimer Disease Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA

Mini residency

Steven T. DeKosky, M.D

Department of Neurology


Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA

Trainee for the Aging Training Program

Epidemiology of Aging

Design and analysis of structural and functional brain imaging studies in large epidemiologic populations. PI: A B. Newman


Institute for Clinical Research and Education,University of Pittsburgh, Pittsburgh PA


Mentor Training Program

PI: B. Rollman and W.



MDPhD Director for the Department of Epidemiology



EPI2019. Introduction to Multimodal Neuroimaging, SPRING

EPI 2012 - Writing in Population Neuroscience, SUMMER

Selected Publications