Charles R Rinaldo

  • Professor, Pathology

Cellular immunity to human immunodeficiency virus (HIV) and Kaposi's sarcoma associated herpesvirus (KSHV; human herpesvirus 8), clinical virology.

Dr. Rinaldo is Professor of Infectious Diseases and Microbiology (IDM) in the University of Pittsburgh Graduate School of Public Health (GSPH) and Professor of Pathology in the School of Medicine. In 1983, he was successful in establishing a Multicenter AIDS Cohort Study (MACS) site in Pittsburgh, termed the Pitt Men's Study (PMS), which investigates the natural history of AIDS in men who have sex with men in Pittsburgh. The MACS currently has published over 1700 scientific articles, many of which have had significant impact in the field of AIDS research.

Dr. Rinaldo's research is focused on the relation of disease progression to dendritic cell function and reactivity of CD8 killer T cells to HIV and human herpesvirus 8 (HHV-8, or KSHV, the cause of Kaposi's sarcoma). Dr. Rinaldo has mentored many graduate students and postdoctoral fellows, and has had continuous research grant funding from the NIH since 1979.


Undergraduate1964-1966 | Onondaga Community College, Syracuse, NY | A.A., General Studies
1966-1969 | Syracuse University, Syracuse, NY | A.B., Bacteriology

1969-1970 | University of Rochester, Rochester, NY | PhD Candidate, Microbiology
1970-1973 | University of Utah, Salt Lake City, UT | PhD, Microbiology

1973-1974 | Postdoctoral Research Fellow, University of Utah | Microbiology
1974-1977 | Postdoctoral Research Fellow, Massachusetts General Hospital | Infectious Disease
1977-1978 | Research Associate, Massachusetts General Hospital | Infectious Disease


IDM 2003 - Host Response to Microbial Infection
IDM 2038 - Treatment, Prevention and Control of Global Infectious Disease

Pathology Residency Training Program - Teaching of clinical virology to Pathology Residents during their rotation in Clinical Microbiology

Selected Publications

Gandhi, R.T., Cyktor, J.C., Bosch, R.J., Mar, H., Laird, G.M., Martin, A., Collier, A.C., Riddler, S.A., Macatangay, B.J., Rinaldo, C.R., Eron, J.J., Siliciano, J.D., McMahon, D.K., Mellors, J.W.; ACTG A5321 team. Selective decay of intact HIV-1 proviral DNA on antiretroviral therapy. J Infect Dis. 223:225-233, 2021.

Garcia-Bates, T.M., Palma, M.L., Hsu, D.C., Ananworanich, J., Korber, B.T., Gaiha, G.D., Phanuphak N., Thomas, R., Tovanabutra, S., Walker, B.D., Mellors, J.W., Piazza, P.A., Kroon, E., Riddler S.A., Nelson, L., Michael, N.L.,Rinaldo, C.R., and Mailliard, R.B. Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes. EBioMedicine 63:103175, 2021.

Gerberick, A., DeLucia, D.C., Piazza, P., Alaoui-El-Azher, M.,Rinaldo, C.R., Sluis-Cremer, N., and Rappocciolo, G. B. lymphocytes, but not dendritic cells, efficiently HIV-1trans infect naive CD4+ T cells: implications for the viral reservoir. mBio 12(2):e02998-20, 2021.&nbsp

Falade-Nwulia, O., Seaberg, E.C., Snider, A.E.,Rinaldo, C.R., Wolinsky, S.M., Witt, M.D., and Thio, C.L. Outcomes of acute hepatitis B virus (HBV) in HIV infection with and without HBV-active antiretroviral therapy. AIDS 35(6):991-993, 2021.

Read, J.M., Zimmer, S., Vukotich, C. Jr., Schweizer, M.L., Galloway, D., Lingle, C., Yearwood, G., Calderone, P., Noble, E., Quadelacy, T., Grantz, K.,Rinaldo, C., Gao, H., Rainey, J., Uzicanin, A., and Cummings, D.A.T. Influenza and other respiratory viral infections associated with absence from school among schoolchildren in Pittsburgh, Pennsylvania, USA: a cohort study. BMC Infect Dis. 21:291, 2021.

Macatangay, B.J.C., Gandhi, R.T., Brad Jones, R., McMahon, D.K., Lalama, C.M., Bosch, R.J., Cyktor, J.C., Thomas, A.S., Borowski, L., Riddler, S.A., Hogg, E., Stevenson, E., Eron, J.J., Mellors, J.W.,Rinaldo, C.R.; ACTG A5321 Team. T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy. AIDS 34:15-24, 2020.

Macatangay, B.J.C, Jackson, E.K., Abebe, K.Z., Comer, D., Cyktor, J., Klamar-Blain, C., Borowski, L., Gillespie, D.G., Mellors, J.W.,Rinaldo, C.R., and Riddler SA. A randomized, placebo-controlled, pilot clinical trial of dipyridamole to decrease human immunodeficiency virus-associated chronic inflammation. J Infect Dis. 221:1598-1606, 2020.

Balasubramani, G.K., Nowalk, M.P., Sax, T.M,, Suyama, J., Bobyock, E.,Rinaldo, C.R. Jr., Martin, E.T., Monto, A.S., Jackson, M.L., Gaglani, M.J., Flannery, B., Chung, J.R., and Zimmerman, R.K. Influenza vaccine effectiveness among outpatients in the US Influenza Vaccine Effectiveness Network by study site 2011-2016. Influenza Other Respir Viruses. 14:380-390, 2020.

Rocco, J.M., York, Z., Shen, C., Shiboski, C., Cyriaque-Webster, J., McLaughlin, J., Borowski, L., Chen, H., Aberg, J.A., Dittmer, D.P., Ghannoum, M.,Rinaldo, C.R., and Macatangay, B. Oral cytokine levels are more linked to levels of plasma and oral HIV-1 RNA than to CD4+ T-cell counts in people with HIV. Open Forum Infect Dis. 7:ofaa047, 2020.

Anderko, R.R.,Rinaldo, C.R., and Mailliard, R.B. IL-18 responsiveness defines limitations in immune help for specialized FcR?– NK cells. J. Immunol. 205:3429-3442, 2020.

D’Souza, G., Springer, G., Gustafson, D., Kassaye, S., Alcaide, M.L., Ramirez, C., Sharma, A., Palella, F.J., Tien, P.C., Detels, R., Kempf, M.-C., Lahiri, C.D.,Rinaldo, C.R., French, A.L., Margolick, J.B., and Adimora, A.A. COVID-19 symptoms and SARS-CoV-2 infection among people living with HIV in the US: the MACS/WIHS Combined Cohort Study. HIV Res. Clin. Pract. 21(5):130-139, 2020.