Douglas Reed

PhD
  • Associate Professor, Immunology
  • Associate Professor, Infectious Diseases and Microbiology

Douglas Reed did doctoral work at the University of Texas Southwestern Medical Center at Dallas, working on thymocyte development in vitro. In 1995 he moved to Connecticut to work as a postdoctoral fellow in the laboratory of Leo Lefrancois studying T lymphocyte activation in response to antigens entering through the small intestine.

Reed became a principal investigator at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) in 1999, developing animal models to aerosolized pathogens and conducting efficacy studies in those models. While at USAMRIID Reed conducted and supervised aerosol exposures of animals including rodents, rabbits, and nonhuman primates. He developed nonhuman primate models of aerosol exposure to Venezuelan, Western, and Eastern Equine Encephalitis and evaluating candidate vaccines, developing rodent and nonhuman primate models of aerosol exposure to Marburg and Ebola viruses, and evaluating a GMP-grade recombinant plague vaccine in mice against pneumonic plague.

Reed is currently the aerobiology manager of the Regional Biocontainment Laboratory, working with collaborators to develop animal models of aerosol exposure to pathogens that are either biodefense threats or emerging infectious diseases.

    Education
    • BS in Microbiology from Oklahoma State University
    • MS in Microbiology from Oklahoma State University
    • 1995 | PhD in Immunology from UT Southwestern Medical Center at Dallas
    Selected Publications
    • Ma, Henry, Lundy, J., O’Malley, K., Klimstra, W.B., Hartman, A.L., Reed, D.S. 2019. Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses. Pathogens 8, 240; doi:10.3390/pathogens8040240
    • Bowling, J.D., O’Malley, K.J., Klimstra, W.B., Hartman, A.L., Reed, D.S. 2019. A vibrating mesh nebulizer as an alternative to the Collison 3-jet nebulizer for infectious disease aerobiology. Applied & Environmental Microbiology. Aug 14;85(17) PMID 31253680
    • O'Malley, K., Bowling, J.D., Hazlett, K.R.O., Barry, E.M., Reed, D.S. 2019. Development, characterization and standardization of a nose-only inhalation exposure system for exposure of rabbits to small particle aerosols containing Francisella tularensis. Infection & Immunity. pii: IAI.00198-19 PMID: 31085702
    • Albe, J., Boyles, D.A., Walters, A.W., Kujawa, M.R., McMillen, C.M., Reed, D.S., Hartman, A.L. 2019. Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley Fever encephalitis in rats. PLoS Pathogens. Jun 20;15(6):e1007833 PMID: 31220182
    • Trobaugh, D.W., Sun, C., Reed, D.S., Klimstra,W.B. 2019. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. PLoS Pathogens. Feb 11;15(2):e1007584 PMID: 30742691
    • O’Malley, K., Bowling, J.D., Stinson, E., Cole, K.S., Mann, B.J., Namjoshi, P., Hazlett, K.R.O.*, Barry, E.M.*, Reed, D.S.* 2018. Aerosol prime-boost vaccination with defined, attenuated mutants of type A Francisella tularensis provides strong protection in outbred rabbits against lethal aerosol challenge with virulent SCHU S4. PLoS ONE Oct 22;13(10):e0205928 PMID: 30346998 * - equal contribution

    Complete List of Publications

     

    Department/Affiliation