Greg Yothers

  • Research Professor, Biostatistics
  • Senior Deputy Director and Deputy Group Statistician, NRG Oncology SDMC

My primary research interest is the design, implementation and analysis of phase II and III clinical trials for cancer research. My work with the NRG Oncology clinical trials group has included trials evaluating therapies for the treatment of colon, rectal, and breast cancer. The focus of my methodological research has been the development of statistical methodologies for identifying a subset of a clinical trial population where a treatment is effective.

I am one of the Primary Investigators for the NRG Oncology Statistics
and Data Management Center (SDMC) - a clinical trials research group comprising
200+ employees. I am the Senior Deputy Director and Deputy Group Statistician for NRG
Oncology SDMC.


2003 | University of Pittsburgh, Pittsburgh, PA | Doctor of Philosophy in Statistics

1998 | University of Pittsburgh, Pittsburgh, PA | Master of Arts in Statistics
1981 | Pennsylvania State University, State College, PA | Bachelor of Science in Mathematics

Selected Publications

1. Dasari, A., Morris, V. K., Allegra, C. J., Atreya, C., Benson, A. B., Boland P., Chung K., Copur, M. S., Corcoran, R. B., Deming, D. A., Dwyer, A., Diehn, M., Eng, C., George, T. J., Gollub, M. J., Goodwin, R. A., Hamilton, S. R., Hechtman, J. F., Hochster, H., Hong, T. S., Innocenti, F., Iqbal, A., Jacobs, S. A., Kennecke, H. F., Lee, J. J., Lieu, C. H., Lenz, H. J., Lindwasser, O. W., Montagut, C., Odisio, B., Ou, F. S., Porter, L., Raghav, K., Schrag, D., Scott, A. J., Shi, Q., Strickler, J. H., Venook, A., Yaeger, R., Yothers, G., You, Y. N., Zell, J. A., Kopetz, S., ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.Nature Reviews. Clinical Oncology. Dec 2020. 17(12):757-770,

2. Gresham, G., Diniz, M. A., Razaee, Z. S., Luu, M., Kim, S., Hays, R. D., Piantadosi, S., Tighiouart, M., Yothers, G., Ganz, P. A., Rogatko, A., Evaluating Treatment Tolerability in Cancer Clinical Trials using the Toxicity Index.Journal of the National Cancer Institute. Dec14, 2020. 112(12):1266-1274

3. Razaee, Z. S., Amini, A. A., Diniz, M. A., Tighiouart, M., Yothers, G., Rogatko, A., On the properties of the toxicity index and its statistical efficiency.Stat Med, Mar 15, 2021. 40(6):1535-1552.

4. Wagner, A. D., Grothey, A., Andre, T., Dixon, J. G., Wolmark, N., Haller, D. G., Allegra, C. J., de Gramont, A., VanCutsem, E., Alberts, S. R., George, T. J., O'Connell, M. J., Twelves, C., Taieb, J., Saltz, L. B., Blanke, C. D., Francini, E., Kerr, R., Yothers, G., Seitz, J. F., Marsoni, S., Goldberg, R. M., Shi, Q., Sex and adverse events of adjuvant chemotherapy in colon cancer: an analysis of 34,640 patients in the ACCENT database.Journal of the National Cancer Institute, Apr 2021. 113(4):400-407.

5. Tutt, A. N. J., Garber, J. E., Kaufman, B., Viale, G., Fumagalli, D., Rastogi, P., Gelber, R. D., de Azambuja, E., Fielding, A., Balmaña, J., Domchek, S. M., Gelmon, K. A., Hollingsworth, S. J., Korde, L. A., Linderholm, B., Bandos, H., Senkus, E., Suga, J. M., Shao, Z., Pippas, A. W., Nowecki, Z., Huzarski, T., Ganz, P. A., Lucas, P. C., Baker, N., Loibl, S., McConnell, R., Piccart, M., Schmutzler, R., Steger, G. G., Costantino, J. P., Arahmani, A., Wolmark, N., McFadden, E., Karantza, V., Lakhani, S. R., Yothers, G., Campbell, C., Geyer, C. E. Jr; OlympiA Clinical Trial Steering Committee and Investigators, Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer.N Engl J Med, Jun 3, 2021. EPub ahead of print