Guillermo Rodriguez Bey

PhD, MSc
  • Research Assistant Professor

Dr. Bey’s research focuses on neurological pathologies, looking for the different pathways that regulate the expression of genes related to those pathologies. To achieve this, he works with mice, cells, and human models. In addition, his research focuses on bringing therapeutic approximations that could relieve the symptoms of those neurodegenerative pathologies. Understanding the different signaling pathways and gene regulation at the RNA and protein level is one of the keys to better understanding the roots of neurological disorders.

Research interests:

Molecular biology and genetics of different neurological disorders. Therapeutic approximation. Gene expression and neurophysiology.


2015 | University of Pittsburgh, PA| Postdoctoral associate, Padiath lab.

2014 | University of Cádiz, Andalucía, Spain | PhD in Health Sciences

2008 | University of Seville, Andalucía, Spain | MS. Molecular genetics and Biotech

2005 | University of Seville, Andalucía, Spain | BS in Biology


HUGEN2032: Genetic Techniques

Students participate in laboratory exercises to become acquainted with cytogenetics
laboratory procedures including cell culture, chromosome preparation, chromosome banding,
and karyotyping. Chromosome analysis and karyotype interpretation are practiced.

Selected Publications

Google Scholar profile

Orcid ID

Variants in the zinc transporter TMEM163 cause a hypomyelinating leukodystrophy. Guillermo Rodriguez Bey, Michelle C do Rosario, Guillermo Rodriguez Bey, Bruce Nmezi, Fang Liu, Talia Oranburg, Ana S A Cohen, Keith A Coffman, Maya R Brown, Kirill Kiselyov, Quinten Waisfisz, Myrthe T Flohil, Shahyan Siddiqui, Jill A Rosenfeld, Alejandro Iglesias, Katta Mohan Girisha, Nicole I Wolf, Quasar Saleem Padiath, Anju Shukla.  Brain. August 2022

Interfering with lysophosphatidic acid receptor edg2/lpa1 signaling slows down disease progression in SOD1‐G93A transgenic mice. Ángela Gento‐Caro, Esther Vilches‐Herrando, Victoria García‐Morales, Federico Portillo, Guillermo Rodríguez‐Bey, David González‐Forero, Bernardo Moreno‐López. Neuropathol Appl Neurobiol. 2021;00:1–15

Conditional depletion of Fus in oligodendrocytes leads to motor hyperactivity and increased myelin deposition associated with Akt and cholesterol activation. Kelly M Guzman, Lauren E Brink, Guillermo Rodriguez‐Bey, Richard J Bodnar, Lisha Kuang, Bin Xing, Mara Sullivan, Hyun J Park, Erik Koppes, Haining Zhu, Quasar Padiath, Franca Cambi. Glia. March 2020, 1– 17

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. Victoria García-Morales*, Guillermo Rodríguez-Bey*, Laura Gómez-Pérez*, Germán Domínguez-Vías, David González-Forero, Federico Portillo, Antonio Campos-Caro, Ángela Gento-Caro, Noura Issaoui, Rosa M Soler, Ana Garcera, Bernardo Moreno-López. Nature Communications. August 2019, Volume 10, Article number: 3784 (2019)  

Concentric organization of A-and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina. Bruce Nmezi, Jianquan Xu, Rao Fu, Travis J Armiger, Guillermo Rodriguez-Bey, Juliana S Powell, Hongqiang Ma, Mara Sullivan, Yiping Tu, Natalie Y Chen, Stephen G Young, Donna B Stolz, Kris Noel Dahl, Yang Liu, Quasar S Padiath. Proceedings of the National Academy of Sciences. PNAS March 5, 2019, 116 (10) 4307-4315

TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes. Julian Curie*, Guillermo Rodríguez Bey*, Asako Takanohashi, Marianna Bugiani5, Xiaoqin Fu , Nicole I Wolf5 , Bruce Nmezi , Raphael Schiffmann , Mona Bugaighis , Tyler Pierson , Guy Helman, Cas Simons , Marjo S van der Knaap , Judy Liu, Quasar Padiath, Adeline Vanderver. Human Molecular Genetics. 29 August 2017 (* Shared first authorship)

Membrane-derived phospholipids control synaptic neurotransmission and plasticity. Victoria García-Morales, Fernando Montero, David González-Forero, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, María Jesús Medialdea-Wandossell, Germán Domínguez-Vías, José Manuel García-Verdugo, Bernardo Moreno-López. PLoS Biology. 2015 May 21;13(5):e1002153