Undergraduate
2001 | Aligarh Muslim University, Aligarh, UP, India | Bachelor of Science | Chemistry
Graduate
2003 | School of Biotechnology, University of Jammu, Jammu, J&K, India | Master of Science | Biotechnology
2011 | Institute of Microbial Technology/Jawaharlal Nehru University, New Delhi, India | Ph. D | Biochemistry and Molecular Biology
Post-Graduate
2011-2014 | Research Center, Hospital Maisonneuve- Rosemont (HMR), University of Montreal, Quebec, Canada. | Postdoctoral Fellow | Biochemistry and Cell Biology.
2014-2014 | McMaster University, Hamilton, Onterio, Canada | Visiting Fellow | Microbiology
2017-2020 | EOH 2310: Molecular Fundamentals
H. H. Dar, et al., (2022). P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis.JCI Insight;7(4): e156013.https://doi.org/10.1172/jci.insight.156013 (PMID: 35041620).
A. M. Lamade, L. Wu,H. H. Dar, et al., (2022). Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death.Redox Biology;50:102232.https://doi.org/10.1016/j.redox.2022.102232.(PMID:35101798).
H. H. Dar, T. S. Anthonymuthu, P. A. Ponomareva et al., (2021). A new thiol- independent mechanism of epithelial host defense against Pseudononas aeruginosa: iNOS/NO sabotage of theft-ferroptosis. (Redox Biology. 45, 102045.https://doi.org/10.1016/j.redox.2021.102045 (*Co-corresponding author). (PMID: 34167028).).
W. Y. Sun, V. A. Tyurin, I. H. Shrivastava, B. Liu, Y. J. Zhai, S. Korolev, A. Y. Abramov, P. R. Angelova, O. Beharier,H. H. Dar, et al., (2021). Phospholipase iPLA 2 � averts fer- roptosis by eliminating a redox lipid death signal.Nature Chemical Biology. 17, 465-476.(PMID:33542532).
T. S. Anthonymuthu, Y. Y. Tyurina, W. Y. Sun, K. Mikulska-Ruminska, I. H. Shrivastava, V. A. Tyurin, F. B. Cinemre,H. H. Daret al., (2021) Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of perox- idized ETE-PE, and protects against ferroptosis.Redox Biology.Jan;38:101744. (PMID: 33126055).
J. Zhao,H. H. Dar, Y. Deng, C. M. St Croix, Z. Li, Y. Minami et al., (2020). PEBP1 acts as a Rheostat between Pro-survival Autophagy and Ferroptotic Death in Asthmatic Epithelial Cells.Proc Natl Acad Sci U S A. 17(25):14376-14385. (PMID:32513718).
A. Kapralov*, Q. Yang*,H. H. Dar*, et al., (2020). Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.Nature Chemical Biology.16:278-290.(PMID:32080625) (* Equal contribution).
T. Anthonymuthu, E. M. Kenny, I. Shrivastava, Y. Y. Tyurina, Z. E. Hier, H.C. Ting,H. H. Dar, et al., (2018). Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE.J. Am. Chem. Soc. 140 (51):17835-17839. (PMID:30525572).
H. H. Dar, Y. Y. Tyurina, K. Mikulska-Ruminska, I. Shrivastava, H.C. Ting, et al., (2018). Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium.Journal of Clinical Investigation. 128 (10):4639-4653. (PMID:30198910).
S. E. Wenzel, Y. Y. Tyurina, J. Zhao, C. M. St. Croix,H. H. Dar, et al., (2017). PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death SignalsCell. 171(3):628-641. (PMID:29053969).
C. F. Chiu,H. H. Dar, A. A. Kapralov, R. A. S. Robinson, V. E. Kagan and A. Star (2017). Nano emitters and innate immunity: the role of surfactants in myeloperoxidase-catalyzed ox- idation of pristine single-walled carbon nanotubes.Nanoscale. 9 (18):5948-5956. (PMID:28440832).
V. E. Kagan, G. Mao, F. Qu, J. P. F. Angeli, S. Doll, C. St. Croix,H. H. Dar, et al., (2017). Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.Nature Chemical Biology. 13(1):81-90. (PMID:27842066).
V. E. Kagan, J. Jiang, Z. Huang, Y. Y. Tyurina, C. Desbourdes, C. Cottet-Rousselle,H. H. Dar, et al., (2016). NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy.Cell Death Differ. 23(7):1140-51. (PMID:26742431).
K. Balasubramanian, A. Maeda, J. S. Lee, D. Mohammadyani,H. H. Dar, et al (2015). Di- chotomous roles for externalized cardiolipin in extracellular signaling: Promotion of phago- cytosis and attenuation of innate immunity.Science Signaling.Sep 22;8(395): ra95. (PMID:26396268).
N. Mashtalir, S. Daou, N. Sen, J. Gagnon, I. Hammon-Martel,H. H. Dar, M. Therrien and El B. Affar (2014). Autodeubiquitination protects the tumor suppressor BAP1 from cyto- plasmic sequestration mediated by atypical Ubiquitin ligase UBE2O.Mol Cell. May 8;54(3):392-406. (PMID:24703950).
H. H. Dar, D. Prasad, G. C. Varshney and P. K. Chakraborti (2011). Secretory Nucleoside diphosphate Kinase from both the Intra- and Extra- cellular Pathogenic Bacteria are function- ally indistinguishable.Microbioloby. 157, 3024-35. (PMID:21816881).
H. H. Darand P. K. Chakraborti (2010). Intermolecular phosphotransfer is crucial for efficient catalytic activity of Nucleoside diphosphate kinase.Biochem J. 430, 539-549. (PMID:20575762).
R. Saxena, P. Kanudia, M. Datt,H. H. Dar, S. Karthikeyan, B. Singh and P. K. Chakraborti (2008). Three consecutive arginine’s are important for mycobacterial peptide deformylase enzyme activity.J. Biol. Chem. 283, 23754-23764. (PMID:18574247).
