Hong Wang

  • Research Associate Professor

Primary areas of research interest are design and statistical analysis of pre-clinical studies and phase I/II clinical trials, and frailty models in survival analysis. Other areas of interest include in vitro and in vivo radiation survival analysis.


1988, Peking University, Peking, China, BS of Probability and Statistics
1994, Peking University, Peking, China, MS of Probability and Statistics
2004, Medical College of Wisconsin, Milwaukee, WI, PhD of Biostatistics

Selected Publications

1. Matsumoto M, Wack S, Weinstock MA, Geller A, Wang H, Solano FX, Kirkwood JM, Ferris LK. Five-Year Outcomes of a Melanoma Screening Initiative in a Large Health Care System. JAMA Dermatol. 2022 May 1;158(5):504-512. doi: 10.1001/jamadermatol.2022.0253. PMID: 35385051; PMCID: PMC8988026.

2. Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363. PMID: 33542131; PMCID: PMC8097968.

3.    Thomas J, Wang H, Clump DA, Ferris RL, Duvvuri U, Ohr J, Heron DE. Long-Term Patient-Reported Quality of Life After Stereotactic Body Radiation Therapy for Recurrent, Previously-Irradiated Head and Neck Cancer. Front Oncol. 2020 Feb 5;10:83. doi: 10.3389/fonc.2020.00083. PMID: 32117738; PMCID: PMC7013096.

4.    Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayir H. Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury. Crit Care Med. 2019 Mar;47(3):410-418. doi: 10.1097/CCM.0000000000003555. PubMed PMID: 30531185; PubMed Central PMCID: PMC6449247.
5.    Sutera P, Clump DA, Kalash R, D'Ambrosio D, Mihai A, Wang H, Petro DP, Burton SA, Heron DE. Initial Results of a Multicenter Phase 2 Trial of Stereotactic Ablative Radiation Therapy for Oligometastatic Cancer. Int J Radiat Oncol Biol Phys. 2019 Jan 1;103(1):116-122. doi: 10.1016/j.ijrobp.2018.08.027. Epub 2018 Aug 25. PubMed PMID: 30149056.
6.    Davar D, Wang H, Chauvin JM, Pagliano O, Fourcade JJ, Ka M, Menna C, Rose A, Sander C, Borhani AA, Karunamurthy A, Tarhini AA, Tawbi HA, Zhao Q, Moreno BH, Ebbinghaus S, Ibrahim N, Kirkwood JM, Zarour HM. Phase Ib/II Study of Pembrolizumab and Pegylated-Interferon Alfa-2b in Advanced Melanoma. J Clin Oncol. 2018 Oct 25:JCO1800632. doi: 0.1200/JCO.18.00632. [Epub ahead of print] PubMed PMID: 30359157; PubMed Central PMCID: PMC6286160.
7.    Dar HH, Tyurina YY, Mikulska-Ruminska K, Shrivastava I, Ting HC, Tyurin VA, Krieger J, St Croix CM, Watkins S, Bayir E, Mao G, Armbruster CR, Kapralov A, Wang H, Parsek MR, Anthonymuthu TS, Ogunsola AF, Flitter BA, Freedman CJ, Gaston JR, Holman TR, Pilewski JM, Greenberger JS, Mallampalli RK, Doi Y, Lee JS, Bahar I, Bomberger JM, Bayır H, Kagan VE. Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium. J Clin Invest. 2018 Oct 1;128(10):4639-4653. doi: 10.1172/JCI99490. Epub 2018 Sep 10. PubMed PMID: 30198910; PubMed Central PMCID: PMC6159971.
8.    Sutera PA, Bernard ME, Wang H, Heron DE. Prognostic Factors for Elderly Patients Treated With Stereotactic Body Radiation Therapy for Pancreatic Adenocarcinoma. Front Oncol. 2018 Jul 27;8:282. doi: 10.3389/fonc.2018.00282. eCollection 2018. PubMed PMID: 30101127; PubMed Central PMCID: PMC6072866.
9.    Fourcade J, Sun Z, Chauvin JM, Ka M, Davar D, Pagliano O, Wang H, Saada S, Menna C, Amin R, Sander C, Kirkwood JM, Korman AJ, Zarour HM. CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018 Jul 26;3(14). pii: 121157. doi: 10.1172/jci.insight.121157. eCollection 2018 Jul 26. PubMed PMID: 30046006;    PubMed Central PMCID: PMC6124410.
10.    Sutera P, Bernard ME, Wang H, Bahary N, Burton S, Zeh H, Heron DE. Stereotactic Body Radiation Therapy for Locally Progressive and Recurrent Pancreatic Cancer after Prior Radiation. Front Oncol. 2018 Mar 7;8:52. doi: 10.3389/fonc.2018.00052. eCollection 2018. PubMed PMID: 29564223; PubMed Central PMCID: PMC5845878.
11.  Mehta K, Im A, Rahman F, Wang H, Veldkamp P. Epidemiology and Outcomes of Hematopoietic Stem Cell Transplant in HIV (+) Patients from 1998 to 2012: A Nationwide Analysis. Clin Infect Dis. 2018 Jan 6. doi: 10.1093/cid/ciy010. [Epub ahead of print] PubMed PMID: 29325063.
12.     Achkar T, Arjunan A, Wang H, Saul M, Davar D, Appleman LJ, Friedland D, Parikh RA. High-dose interleukin 2 in patients with metastatic renal cell carcinoma with sarcomatoid features. PLoS One. 2017 Dec 20;12(12):e0190084. doi: 10.1371/journal.pone.0190084. eCollection 2017. PubMed PMID: 29261796; PubMed Central PMCID: PMC5738119.
13.     Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, Greenberger JS. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiat Res. 2018 Jan;189(1):68-83. doi: 10.1667/RR14787.1. Epub 2017 Nov 15. PubMed PMID: 29140165; PubMed Central PMCID: PMC5808408.
14.     Boyiadzis M, Agha M, Redner RL, Sehgal A, Im A, Hou JZ, Farah R, Dorritie KA, Raptis A, Lim SH, Wang H, Lapteva N, Mei Z, Butterfield LH, Rooney CM, Whiteside TL. Phase 1 clinical trial of adoptive immunotherapy using "off-the-shelf" activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia. Cytotherapy. 2017 Oct;19(10):1225-1232. doi: 10.1016/j.jcyt.2017.07.008. Epub 2017 Aug 30. PubMed PMID: 28864289.
15.    Eiseman JL, Sciullo M, Wang H, Beumer JH, Horn CC. Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis. Lab Anim. 2017 Oct;51(5):534-537. doi:10.1177/0023677217695851. Epub 2017 Feb 26. PubMed PMID: 28948895; PubMed Central PMCID: PMC5654602..
16.    Wang H, Zhang X. Confidence Band for the Difference between Two Direct Adjusted Survival Curves. Journal Of Statistical Software 2016. 70: 1-17
17.    Maxwell JH, Rath TJ, Byrd JK, Albergotti WG, Wang H, Duvvuri U, Kim S, Johnson JT, Branstetter BF 4th, Ferris RL. Accuracy of computed tomography to predict extracapsular spread in p16-positive squamous cell carcinoma. The Laryngoscope. 2015 May 6. PMID: 25946149. doi: 10.1002/lary.25140.
18.    Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sander C, Kirkwood JM, Chen TH, Maurer M, Korman AJ, Zarour HM. TIGIT and PD-1 impair tumor antigen-specific CD8+ T cells in melanoma patients. The Journal of Clinical Investigation. 2015 May 1; 125 (5):2046-58. PMID: 25866972. doi: 10.1172/JCI80445.
19.    Ling DC, Kabolizadeh P, Heron DE, Ohr JP, Wang H, Johnson J, Kubicek GJ. Incidence of hospitalization in patients with head and neck cancer treated with intensity-modulated radiation therapy. Head & Neck. 2014 Jul 2. PMID: 24986324. doi: 10.1002/hed.23821.
20.    Fourcade J, Sun Z, Pagliano O, Chauvin J, Sander C, Janjic B, Tarhini A, Tawbi HA, Kirkwood J, Moschos S, Wang H, Guillaume P, Luescher I, Krieg A, Anderson A, Kuchroo V, Zarour H. PD-1 and Tim-3 Regulate the Expansion of Tumor Antigen-specific CD8¿ T Cells Induced by Melanoma Vaccines. Cancer Research. 2014 Feb; 74 (4):1045-55. PMCID: 3952491. PMID: 24343228.
22.    Horn CC, Wang H, Estival L, Meyers K, Magnusson MS. Novel dynamic measures of emetic behavior in musk shrews. Autonomic Neuroscience : Basic & Clinical. 2013 Dec; 179:60-7. PMCID: PMC3844068. PMID: 23953843.
22.    Qiu W, Liu H, Sebastini A, Sun Q, Wang H, Zhang L, Yu J. An Apoptosis-independent Role of SMAC in Tumor Suppression. Oncogene. 2013 May 9; 32 (19):2380-9. PMCID: 3751796. PMID: 22751125.
23.    Horn C, Kimball B, Wang H, Kaus J, Dienel S, Nagy A, Gathright G, Yates BJ, Andrews PL. Why Can’t Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study. PLoS One. 2013 Apr 8; 8 (4)::e60537. PMCID: 3622671. PMID: 23593236.
24.    Wang H, Klein J. Semiparametric estimation for the additive inverse gaussian frailty model. Communications in Statistics - Theory and Methods. 2012; 41 (12):2269-2278.
25.    Wang W, Edington HD, Rao UN, Jukic DM, Radfar A, Wang H, Shipe-Spotloe J, Kirkwood J. Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Dec 15; 14 (24):8314-20. PMID: 19088050.
26.    Oton AB, Wang H, Leleu X, Melhem MF, George D, Lacasce A, Foon K, Ghobrial IM. Clinical and pathological prognostic markers for survival in adult patients with post-transplant lymphoproliferative disorders in solid transplant. Leukemia and Lymphoma. 2008 Sep; 49 (9):1738-44. PMID: 18798108.
27.    Wang W, Edington HD, Rao UN, Jukic DM, Wang H, Shipe-Spotloe JM, Kirkwood JM. STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: dose-response effects of systemic IFNalpha therapy. The Journal of investigative dermatology. 2008 Aug; 128 (8):1997-2002. PMID: 18305569.
28.    Niu Y, Epperly MW, Shen H, Smith T, Wang H, Greenberger J. Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium. Gene Therapy. 2008 Mar; 15 (5):347-56. PMID: 18097469.
29.    Logan BR, Wang H, Zhang MJ. Pairwise multiple comparison adjustment in survival analysis. Statistics in Medicine. 2005 Aug; 24 (16):2509-23. PMID: 15977296.
30.    Bahnson A, Athanassiou C, Koebler D, Qian L, Shields D, Yu H, Wang H, Goff J, Cheng T, Houck R, Cowsert L. Automated measurement of cell motility and proliferation. BMC Cell Biology. 2005 Apr; 6 (1):19. PMCID: PMC1097721. PMID: 15831094.
31.    Wang H. On the confidence limits for the mean of exponential distribution in the life test with fixed truncation. Chinese Journal of Applied Probability and Statistics. 1996; 12:348-354.Author