L. J Sparvero

  • Senior data analyst, Environmental and Occupational Health

Cornell University, Ithaca, NY, Ph.D. in Chemistry and Chemical Biology

Cornell University, Ithaca, NY, M.S. in Polymer Chemistry

Pennsylvania State University, University Park, PA, B.S. in Chemistry

Selected Publications

Successive high-resolution (H2O)n-GCIB and C60-SIMS imaging integrates multi-omics in different cell types in breast cancer tissue

Tian, Hua;Sparvero, Louis; Anthonymuthu, Tamil; Sun, Wanyang; Amoscato, Andrew; He, Rong-Rong; Bayir, Hülya; Kagan, Valerian; Winograd, Nicholas

Analytical Chemistry 2021 Jun 15;93(23):8143-8151. doi: 10.1021/acs.analchem.0c05311. Epub 2021 Jun 2.

Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS)
Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS, Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayir H.

Angew Chem Int Ed Engl. 2021 May 17;60(21):11784-11788. doi: 10.1002/anie.202102001. Epub 2021 Apr 12.

(Featured in the June 2021 issue of Nature Chemical Biology as a highlighted paper, see "L�ssl, P.An oxPEdition into cell death. Nat Chem Biol 17, 626 (2021). https://doi.org/10.1038/s41589-021-00811-9"

and "Peering into the cellular cycle. Nat Chem Biol 17, 625 (2021). https://doi.org/10.1038/s41589-021-00814-6")

Secondary ion mass spectrometry images cardiolipins and phosphatidylethanolamines at the subcellular level
Tian H*,Sparvero L.J.*, Blenkinsopp P, Amoscato AA, Watkins SC, Bayir H, Kagan VE, Winograd N.
Angew Chem Int Ed Engl. 2019 Mar 4;58(10):3156-3161. doi: 10.1002/anie.201814256.

(given Very Important Paper (VIP) status by the editors, fewer than 5% of the published manuscripts qualify)

Redox lipidomics technology: Looking for a needle in a haystack

Tyurina YY, Tyurin VA, Anthonymuthu T, Amoscato AA, Sparvero LJ, Nesterova AM, Baynard ML, Sun W, He R, Khaitovich P, Vladimirov YA, Gabrilovich DI, Bayir H, Kagan VE.

Chem Phys Lipids. 2019 Mar 27;221:93-107. doi: 10.1016/j.chemphyslip.2019.03.012.

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel, Yulia Y. Tyurina, Jinming Zhao, Claudette M. St. Croix, Haider H. Dar, Gaowei Mao, Vladimir A. Tyurin, Tamil S. Anthonymuthu, Alexandr A. Kapralov, Andrew A. Amoscato, Karolina Mikulska-Ruminska, Indira H. Shrivastava, Elizabeth M. Kenny, Qin Yang, Joel C. Rosenbaum, Louis J. Sparvero, David R. Emlet, Xiaoyan Wen, Yoshinori Minami, Feng Qu, Simon C. Watkins, Theodore R. Holman, Andrew P. VanDemark, John A. Kellum, Ivet Bahar, Hülya Bayir, Valerian E. Kagan

Cell Volume 171, Issue 3, p628–641.e26, 19 October 2017

DOI: http://dx.doi.org/10.1016/j.cell.2017.09.044

GCIB-ToF-SIMS high resolution imaging of cardiolipin speciation in the brain: Identification of molecular losses after traumatic injury.
Hua Tian*,L. J. Sparvero*, Andrew A. Amoscato, Anna Bloom,
Hülya Bayir, Valerian E. Kagan, and Nicholas Winograd.
Analytical Chemistry, 2017, 89 (8), pp 4611–4619. * = LJS and HT contributed equally

PMID: 28306235 DOI: 10.1021/acs.analchem.7b00164

Known Unknowns of Cardiolipin Signaling: The Best Is Yet To Come

John J. Maguire, Yulia Y. Tyurina, Dariush Mohammadyani, Aleksandr A. Kapralov, Tamil S. Anthonymuthu, Feng Qu, Andrew A. Amoscato, L. J. Sparvero, Vladimir A. Tyurin, Joan Planas-Iglesias, Rong-Rong He, Judith Klein-Seetharaman, Hülya Bayir, Valerian E. Kagan. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017 Jan;1862(1):8-24. doi: 10.1016/j.bbalip.2016.08.001 PMID: 27498292

Imaging Mass Spectrometry Reveals a Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus after Traumatic Brain Injury

L. J. Sparvero, A. A. Amoscato, A. B. Fink, T. Anthonymuthu, L.E. New, P.M. Kochanek, S. Watkins, V.E. Kagan, and H. Bayir. J Neurochem. 2016 Nov;139(4):659-675. doi: 10.1111/jnc.13840

Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.

Rolyan H, Tyurina YY, Hernandez M, Amoscato AA, Sparvero LJ, Nmezi BC, Lu Y, Est�cio MR, Lin K, Chen J, He RR, Gong P, Rigatti LH, Dupree J, Bayir H, Kagan VE, Casaccia P, Padiath QS.J Neurosci. 2015 Aug 26;35(34):12002-17. doi: 10.1523/JNEUROSCI.1668-15.2015

Imaging mass spectrometry of diversified cardiolipin molecular species in the brain.

Amoscato AA*, Sparvero LJ*, He RR, Watkins S, Bayir H, Kagan VE. Anal Chem. 2014 Jul 1;86(13):6587-95. doi: 10.1021/ac5011876 * = LJS and AAA contributed equally

Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations.

Sparvero LJ, Amoscato AA, Dixon CE, Long JB, Kochanek PM, Pitt BR, Bayir H, Kagan VE. Chem Phys Lipids. 2012 Jul;165(5):545-62. doi: 10.1016/j.chemphyslip.2012.06.001. PMID: 22692104