Maria M Brooks

  • Professor and Co-Director, Epidemiology Data Center
  • Faculty in Epidemiology and Biostatistics

My research has focused on the design, conduct, and analysis of multicenter clinical trials and cohort studies. Most of my work has involved the evaluation of treatments and risk factors in patients with coronary artery disease, diabetes and blood disorders and the epidemiology of cardiovascular diseases and women’s health. I am the Principal Investigator of the Coordinating Center of the Study of Women's Health Across the Nation (SWAN), a multi-racial/ethnic longitudinal cohort study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition. In addition, I am the Principal Investigator of the Data Coordinating Center for the Myocardial Ischemia and Transfusion (MINT) trial, a multicenter randomized clinical trial evaluating transfusion strategies for patients with acute myocardial infarction and anemia and of the Data Coordinating Center for the Sickle Cell Disease and Cardiovascular Risk - Red cell Exchange (SCD-CARRE) trial, a randomized clinical trial evaluating the effectiveness of automated exchange transfusion for adult patients with sickle cell disease. Over the years, I have collaborated on projects involving infectious diseases including COVID-19, behavioral interventions and genetics. I teach advanced epidemiological methods.


1985 | Williams College, Williamstown, MA | Bachelor of Arts, Mathematics, cum laude
1986 | Harvard University, Cambridge, MA | Master of Arts, Statistics

1991 | University of North Carolina, Chapel Hill, NC | PhD, Statistics


2006-2012 | EPIDEM 2180: Epidemiological Methods 1
2012-2018 | EPIDEM 2187: Epidemiological Methods 2
2019-2022 | EPIDEM 2180: Epidemiological Methods 1

Selected Publications
  • Brooks MM, Wisniewski SR. Assessing Unexpected Circumstances That Lead to Modifications in Clinical Trial Design, Conduct, or Analysis: Application of the CONSERVE Reporting Guideline.JAMA. 2022 Mar 1;327(9):868-869. doi: 10.1001/jama.2022.1748. PMID: 35230410.
  • Zhong Y, Brooks MM, Kennedy EH, Bodnar LM, Naimi AI. Use of Machine Learning to Estimate the Per-Protocol Effect of Low-Dose Aspirin on Pregnancy Outcomes: A Secondary Analysis of a Randomized Clinical Trial.JAMA Network Open. 2022 Mar 1;5(3):e2143414. doi: 10.1001/jamanetworkopen.2021.43414. PMID: 35262718; PMCID: PMC8908068.
  • Connors JM, Brooks MM, Sciurba FC, Krishnan JA, Bledsoe JR, Kindzelski A, Baucom AL, Kirwan BA, Eng H, Martin D, Zaharris E, Everett B, Castro L, Shapiro NL, Lin JY, Hou PC, Pepine CJ, Handberg E, Haight DO, Wilson JW, Majercik S, Fu Z, Zhong Y, Venugopal V, Beach S, Wisniewski S, Ridker PM; ACTIV-4B Investigators. Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial.JAMA. 2021 Nov 2;326(17):1703-1712. doi: 10.1001/jama.2021.17272. PMID: 34633405; PMCID: PMC8506296.
  • REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.The New England Journal of Medicine. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4. PMID: 34351722; PMCID: PMC8362592.
  • ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators. Therapeutic Anticoagulation with Heparin in Non-critically Ill Patients with Covid-19.The New England Journal of Medicine. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4. PMID: 34351721; PMCID: PMC8362594.
  • Conzuelo-Rodriguez G, Bodnar LM, Brooks MM, Wahed A, Kennedy EH, Schisterman E, Naimi AI. Performance evaluation of parametric and nonparametric methods when assessing effect measure modification.American Journal of Epidemiology. 2022 Jan 1;191(1):198-207. doi: 10.1093/aje/kwab220. PMID: 34409985; PMCID: PMC8897998.
  • Hutchins F, Krafty R, El Khoudary SR, Catov J, Colvin A, Barinas-Mitchell E, Brooks MM. Gestational weight gain and long-term maternal obesity risk: A multiple bias analysis.Epidemiology. 2021 Mar 1;32(2):248-258. PMID: 33284167. PMCID: PMC7855686.
  • Reeves AN, Elliott MR, Brooks MM,Karvonen-Gutierrez CA, Bondarenko I,Hood MM, Harlow SD. Symptom Clusters Predict Risk of Metabolic-Syndrome and Diabetes in Midlife: The Study of Women’s Health Across the Nation.Annals of Epidemiology. 2021 Feb 22;58:48-55. doi: 10.1016/j.annepidem.2021.02.011. PMID: 33631313. PMCID: In Process.
  • Bertolet M, Brooks MM, Ragni MV. The design of a Bayesian platform trial to prevent and eradicate inhibitors in patients with hemophilia.Blood Advances. 2020 Nov 10;4(21):5433-5441. PMID: 33156923. PMCID: PMC7656929.
  • Barinas-Mitchell E, Duan C, Brooks M, El Khoudary SR, Thurston RC, Matthews KA, Jackson EA, Lewis TT, Derby CA.Cardiovascular Disease Risk Factor Burden During the Menopause Transition and Late Midlife Subclinical Vascular Disease: Does Race/Ethnicity Matter?Journal of the American Heart Association. 2020 Feb 18;9(4):e013876. doi: 10.1161/JAHA.119.013876. PMID:32063114. PMCID: PMC7070180.
  • El Khoudary SR, Chen X, Nasr A, Billheimer J, Brooks MM, McConnell D, Orchard T, Crawford S, Matthews KA, Rader DJ. HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition: SWAN-HDL Study.Arterioscler Thromb Vasc Biol. 2020 Dec 3;ATVBAHA120315355. PMID: 33267661. PMCID: In Process.
  • Yu YH, Bodnar LM, Brooks MM, Himes KP, Naimi AI. Comparison of Parametric and Nonparametric Estimators for the Association Between Incident Prepregnancy Obesity and Stillbirth in a Population-Based Cohort Study.American Journal of Epidemiology. 2019 Jul 1;188(7):1328-1336. PMID: 31111944. PMCID: PMC6657564
  • Matthews KA, El Khoudary SR, Brooks MM, Derby CA, Harlow SD, Barinas-Mitchell EJ, Thurston RC. Lipid Changes Around the Final Menstrual Period Predict Carotid Subclinical Disease in Postmenopausal Women.Stroke. 2017 Jan;48(1):70-76. PMID: 27909203. PMCID: PMC5183479.
  • Bertolet M, Brooks MM, Bittner V. Tree-based identification of subgroups for time-varying covariate survival data.Statistical Methods in Medical Research. 2016 Feb: 25(1):488-501. PMID: 23070595. PMCID: PMC5575747.
  • Tepper PG,Brooks MM,Randolph JF Jr,Crawford SL,El Khoudary SR,Gold EB,Lasley BL,Jones B,Joffe H,Hess R,Avis NE,Harlow S,McConnell DS,Bromberger JT,Zheng H,Ruppert K,Thurston RC. Characterizing the trajectories of vasomotor symptoms across the menopausal transition.Menopause. 2016 Oct; 23(10):1067-74. PMID: 27404029. PMCID: PMC5028150.
  • Mancini GB, Farkouh ME, Brooks MM, Chaitman BR, Boden WE, Vlachos H, Hartigan PM, Siami FS, Sidhu MS, Bittner V,Frye R, Fuster V. Medical Treatment and Revascularization Options in Patients with Type 2 Diabetes and Coronary Disease.Journal of the American College of Cardiology. 2016 Sep 6;68(10):985-95. PMID:27585501. PMCID: N/A.
  • Everett B, Brooks MM, Vlachos HE, Chaitman B, Frye RL, Bhatt DL; BARI 2D Study Group. Troponin and cardiac events in stable ischemic heart disease and diabetes. The New England Journal of Medicine. 2015 Aug 13;373(7):610-20. PMID: 26267622. PMCID: PMC4627639
  • Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease.American Heart Journal. 2013 Jun; 165(6):964-971.e1. PMID: 23708168. PMCID: PMC3664840
  • Brooks MM, Chaitman BR, Nesto RW, Hardison RM, Feit F, Gersh BJ, Krone RJ, Sako EY, Rogers WJ, Garber AJ, King SB 3rd, Davidson CJ, Ikeno F, Frye RL, BARI 2D Study Group. Clinical and angiographic risk stratification and differential impact on treatment outcomes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.Circulation. 2012 Oct 23; 126 (17):2115-24. PMID: 23008442. PMCID: PMC4104411
  • Brooks MM, Chung SC, Helmy T, Hillegass WB, Escobedo J, Melsop KA, Massaro EM, McBane RD, Hyde P, Hlatky MA. Health status after treatment for coronary artery disease and type 2 diabetes mellitus in the bypass angioplasty revascularization investigation 2 diabetes trial.Circulation. 2010 122:1690-1699. PMID: 20937978. PMCID: PMC2964421.
  • Hllatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ.Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomized trials.Lancet. 2009 Apr 4;373(9670):1190-7. PMID: 19303634. PMCID: N/A
  • The BARI 2D Study Group. Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel BE. A randomized trial of therapies for type 2 diabetes and coronary artery disease.The New England Journal of Medicine. 2009; 360:2503-15. PMID: 19502645. PMCID: PMC2863990.