Marnie Bertolet

  • Associate Professor
  • Faculty in Epidemiology, Biostatistics and Clinical and Translational Science Institute

Contributions to Public Health

with selected publications within the past 5 years

  • Maternal and Child Health: My work in Maternal and Child Health (MCH) has focused on the role of maternal factors that are associated with preterm birth. Much of this work has intersected with the cardiovascular disease contribution and also looked at future maternal health based upon pregnancy factors/complications.
    • Catov JM, Sun B, Lewis CE, Bertolet M, Gunderson EP. Prepregnancy weight change associated with high gestational weight gain. Obesity. 2022 Feb;30(2):524-534. PubMed PMID: 35080338.
    • Sun B, Gunderson EP, Bertolet M, Lopa SH, Bryan SG, Lewis CE, Catov JM. Inflammatory, Metabolic and Endothelial Biomarkers Before and After Pregnancy Complications. Am J Epidemiol. 2024 Apr 17;. PubMed PMID: 38634618.
  • Life-course and aging: My work in this area has encompassed looking at how pregnancy factors impact long term outcomes for the mothers as well as looking at dementia and inflammation factors as people age. 
    • Sun B, Bertolet M, Brooks MM, Hubel CA, Lewis CE, Gunderson EP, Catov JM. Life Course Changes in Cardiometabolic Risk Factors Associated With Preterm Delivery: The 30-Year CARDIA Study. J Am Heart Assoc. 2020 Aug 4;9(15):e015900. doi: 10.1161/JAHA.119.015900. Epub 2020 Jul 22. PMID: 32696706.
    • Ehrenkranz R, Zhu X, Glynn NW, Bertolet M, Berman SB, Hengenius JB, Rosano C. Longitudinal Associations Between Higher Self-Reported Energy, Gait Speed, and Cognition in Older Adults With Fatigue. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2407-2414. PubMed PMID: 37774505; PubMed Central PMCID: PMC10692418.
  • Health Equity: My work in this area focuses on subgroup analyses and studies specifically among Black and other populations of color. This includes studying the different underlying risk factors and how they relate to subclinical cardiovascular disease when studying Japanese populations in Japan compared to US citizens in the United States. My work in MCH focused on Black-White inequities in pregnancy and birth outcomes. In some of my other population-based studies, we found that Black populations spend more time waiting for or obtaining medical care in the clinic (though the amount of face-to-face time with the physician was the same) and more time spent travelling to access care. In addition, I have received a certificate in Diversity and Inclusion as well as the Diversity in the Curriculum award for my work at integrating diversity into my Design and Conduct of Clinical Trials course.
    • Royse SK, Snitz BE, Hengenius JB, Huppert TJ, Roush RE, Ehrenkranz RE, Wilson JD, Bertolet M, Reese AC, Cisneros G, Potopenko K, Becker JT, Cohen AD, Shaaban CE. Unhealthy white matter connectivity, cognition, and racialization in older adults. Alzheimers Dement. 2024 Mar;20(3):1483-1496. 2023 Oct 12. PubMed PMID: 37828730; PubMed Central PMCID: PMC10947965.
  • Clinical Trials (Cardiovascular Disease, Transfusion Medicine). My work on clinical trials includes individual R01 studies and large multicenter international NIH Funded U01 trials. I have been involved with numerous clinical trials as the only statistician, including the Wheel Chair 2 Trial and Statins for Pulmonary and Cardiac Complications of Chronic HIV (SPARC). As a coordinating center representative and/or lead statistician on large multicenter international trials (BARI 2D, MINT and  SCD-CARRE), I created DSMB packets including statistical interim monitoring.
    • Bertolet M, Brooks MM, Ragni MV. The design of a Bayesian platform trial to prevent and eradicate inhibitors in patients with hemophilia. Blood Adv. 2020 Nov 10;4(21):5433-5441. PubMed PMID: 33156923; PubMed Central PMCID: PMC7656929.
    • Carson JL, Brooks MM, Hébert PC, Goodman SG, Bertolet M, Glynn SA, Chaitman BR, Simon T, Lopes RD, Goldsweig AM, DeFilippis AP, Abbott JD, Potter BJ, Carrier FM, Rao SV, Cooper HA, Ghafghazi S, Fergusson DA, Kostis WJ, Noveck H, Kim S, Tessalee M, Ducrocq G, de Barros E Silva PGM, Triulzi DJ, Alsweiler C, Menegus MA, Neary JD, Uhl L, Strom JB, Fordyce CB, Ferrari E, Silvain J, Wood FO, Daneault B, Polonsky TS, Senaratne M, Puymirat E, Bouleti C, Lattuca B, White HD, Kelsey SF, Steg PG, Alexander JH. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023 Dec 28;389(26):2446-2456. PubMed PMID: 37952133; PubMed Central PMCID: PMC10837004.
  • Epidemiological Methods: With a PhD in statistics, I look for ways to use novel or underused statistical techniques, as well as to update or enhance existing methods that do not exactly fit the question at hand. The below manuscripts represent work I did with creating a new Classification and Regression Tree algorithm, Bayesian Analysis, piecewise regression modelling and latent class analysis and inverse probability weighting
    • Layden AJ, Bertolet M, Parks WT, Roberts JM, Adibi JJ, Catov JM. Latent class analysis of placental histopathology: a novel approach to classifying early and late preterm births. Am J Obstet Gynecol. 2022 Aug;227(2):290.e1-290.e21. PubMed PMID: 35288092; PubMed Central PMCID: PMC9308632.
    • Layden AJ, Bertolet M, Parks WT, Adibi JJ, Roberts JM, Catov JM. Prepregnancy obesity and risk of placental inflammation at term: a selection bias analysis. Ann Epidemiol. 2023 Oct;86:25-33.e7. PubMed PMID: 37302673; PubMed Central PMCID: PMC10546767.

A complete list of published work can be found on pubmed

Shippensburg University, Shippensburg, PA BA Mathematics 1993
Cornell University, Ithaca, NY Master of Engineering Operations Research and Industrial Engineering 1995
Carnegie Mellon University, Pittsburgh, PA MS Statistics 2002
Carnegie Mellon University, Pittsburgh, PA PhD Statistics 2008

EPID 2181 Design and Conduct of Clinical Trials (2009 – 2022)
EPID 2193 Machine Learning and Bayesian Analysis (2023 – present)

Guest Lectures in:

EPID 2180 Epidemiologic Methods 1: Class on Survey Sampling Design and Analysis (2012 – 2017)
EPID 2187: Epidemiologic Methods 2: Class on Bayesian Analysis (2012-2017)