My research focuses on the epidemiology and pathogenesis of complication development in type 1 diabetes. I am particularly interested in heterogeneity of diabetes complication risk and utilizing longitudinal data to investigate factors that may contribute to the earlier identification of risk for vascular complications. Currently, I am the PI of an R01 entitled Examining Susceptibility and Resistance Phenotypes to Enhance Understanding of the Genetic Basis of Major Coronary Artery Disease in Type 1 Diabetes which aims to identify genetic variants and inflammatory proteins associated with susceptibility to myocardial infection or fatal CAD in type 1 diabetes. I am also the PI of an American Diabetes Association Junior Faculty Development Award funded project entitled Epigenetics of Glycemic Exposure and Complication Development in Type 1 Diabetes, the goal of which is to examine whether differential DNA methylation improves prediction of type 1 diabetes complications over what is already predicted by long-term blood sugar control. Additionally, I have extensive experience planning and executing statistical analyses of studies in lifestyle modification research. I have served as a statistician on several community-based translational/effectiveness trials, including Physical Activity and Sedentary Behavior Change; Impact on Lifestyle Intervention Effects for Diabetes Translation and Diabetes Prevention Translation Project - The healthy LIFESTYLE Program.
2016 | University of Pittsburgh, Pittsburgh, PA | PhD Epidemiology
2005 | University of Pittsburgh, Pittsburgh, PA | MS Biostatistics
2003 | University of Pittsburgh, Pittsburgh, PA | BS Microbiology
Miller RG, Orchard TJ, Costacou T. Joint 30-year HbA1c and Lipid Trajectories and Mortality in Type 1 Diabetes. Diabetes Research and Clinical Practice. 2022; 185: 109787.
Miller RG, Orchard TJ, Costacou T. 30-Year Cardiovascular Disease in Type 1 Diabetes: Risk and Risk Factors Differ by Long-Term Patterns of Glycemic Control. Diabetes Care. 2022; 45(1): 142-150.
Miller RG, Orchard TJ, Onengut-Gumuscu S, Chen W-M, Rich SS, Costacou T. Heterogeneous Long-Term Trajectories of Glycaemic Control in Type 1 Diabetes. Diabetic Medicine 2021; 38(8): e14545.
Miller RG, Orchard TJ, Costacou T. Risk Factors Differ by First Manifestation of Cardiovascular Disease in Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. Diabetes Research and Clinical Practice. 2020; 163: 108141.
Miller RG, Yu L, Becker DJ, Orchard TJ, Costacou T. Older Age of Childhood Type 1 Diabetes Onset is Associated with Islet Autoantibody Positivity Over 30 Years Later: The Pittsburgh Epidemiology of Diabetes Complications Study. Diabetic Medicine. 2020, Epub ahead of print.
Miller RG, Orchard TJ. Understanding Metabolic Memory: A Tale of Two Studies. Diabetes. 2020; 69(3): 291-299.
Miller RG, Costacou T, Orchard TJ. Risk factor modeling for cardiovascular disease in type 1 diabetes in the Pittsburgh Epidemiology of Diabetes Complications (EDC) study: A comparison to the Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications study. Diabetes. 2019; 68(20): 409-419.
Miller RG, Anderson SJ, Costacou T, Sekikawa A, Orchard TJ. Hemoglobin A1c and Cardiovascular Disease Incidence in Type 1 Diabetes: An Application Of Joint Modeling Of Longitudinal And Time-To-Event Data In The Pittsburgh Epidemiology Of Diabetes Complications (EDC) Study. American Journal of Epidemiology. 2018 Jul; 187(7):1520-1529.
Miller RG, Mahajan HD, Costacou T, Sekikawa A, Anderson SJ, Orchard TJ. A Contemporary Estimate of Total Mortality and Cardiovascular Disease Risk in Young Adults With Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care. 2016 Dec;39(12):2296-2303.
Miller RG, Anderson SJ, Costacou T, Sekikawa A, Orchard TJ. Risk stratification for 25-year cardiovascular disease incidence in type 1 diabetes: Tree-structured survival analysis of the Pittsburgh Epidemiology of Diabetes Complications study. Diab Vasc Dis Res. 2016 Jul;13(4):250-9.
Costacou T, Levy AP, Miller RG, Snell-Bergeon J, Asleh R, Farbstein D, Fickley CE, Pambianco G, de la Vega R, Evans RW, Orchard TJ. Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial. Acta Diabetologica. 2016; 53(2): 243-50.
Miller RG, Secrest AM, Ellis D, Becker DJ, Orchard TJ. Changing impact of modifiable risk factors on the incidence of major outcomes of type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes Care. 2013 Dec;36(12):3999-4006.
Miller RG, Secrest AM, Sharma RK, Songer TJ, Orchard TJ. Improvements in the life expectancy of type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications study cohort. Diabetes. 2012 Nov;61(11):2987-92.