Yulia Y Tyurina

PhD
  • Research Professor, Environmental and Occupational Health

The main focus of my research is to understand the fundamental role of
phospholipids and their oxygenated species in cell death pathways including apoptosis, necroptosis, ferroptosis and mitophagy. My studies discovered that the generation of cardiolipin oxygenated species is essential for the execution of the apoptotic cell death pathway and provide insight into the role of reactive oxygen species in triggering cell death pathways. My significant contribution to a study on the mechanisms responsible for the degradation of injured mitochondria by macroautophagy resulted in the discovery of a new regulatory pathway involved in the quality control of mitochondria realized via elimination of damaged organelles. Particularly, redistribution of cardiolipin from the inner to the outer mitochondrial membrane serves as an “eat-me” signal for the elimination of damaged mitochondria in cells. In addition, my contribution to the investigation of the role of lipid hydroperoxides in ferroptosis revealed a complex lipid oxidation signature associated with the ferroptotic cell death pathway.
 

Education

1988 | Saint Petersburg State University, Saint Petersburg, Russia | Master of Biochemistry

1995 | Institute of Evolutionary Physiology and Biochemistry Russian Academy of Science, Saint Petersburg, Russia | PhD in Biochemistry

Selected Publications

Kapralov AA, Yang Q, Dar HH,Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, Tyurin VA, Ting HC, Wu YL, Gao Y, Shurin GV, Artyukhova MA, Ponomareva LA, Timashev PS, Domingues RM, Stoyanovsky DA, Greenberger JS, Mallampalli RK, Bahar I, Gabrilovich DI, Bayir H, Kagan VE.Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16(3):278-290. doi: 10.1038/s41589-019-0462-8. PMID: 32080625

Hussey GS, Pineda Molina C, Cramer MC, Tyurina YY, Tyurin VA, Lee YC, El-Mossier SO, Murdock MH, Timashev PS, Kagan VE, Badylak SF.Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials. Sci Adv. 2020 Mar 20;6(12):eaay4361. doi: 10.1126/sciadv.aay4361. eCollection 2020 Mar. PMID: 32219161, PMCID:PMC7083606

Bayir H, Anthonymuthu TS, Tyurina YY, Patel SJ, Amoscato AA, Lamade AM, Yang Q, Vladimirov GK, Philpott CC, Kagan VE.Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. Cell Chem Biol. 2020 Apr 16;27(4):387-408. doi: 10.1016/j.chembiol.2020.03.014. Review. PMID: 32275865

Perego M, Tyurin VA, Tyurina YY, Yellets J, Nacarelli T, Lin C, Nefedova Y, Kossenkov A, Liu Q, Sreedhar S, Pass H, Roth J, Vogl T, Feldser D, Zhang R, Kagan VE, Gabrilovich DI.Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils.Sci Transl Med. 2020 Dec 2;12(572):eabb5817. doi: 10.1126/scitranslmed.abb5817

Beharier O, Tyurin VA, Goff JP, Guerrero-Santoro J, Kajiwara K, Chu T, Tyurina YY, St Croix CM, Wallace CT, Parry S, Parks WT, Kagan VE, Sadovsky Y.PLA2G6 guards placental trophoblasts against ferroptotic injury.Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27319-27328. doi: 10.1073/pnas.2009201117.

Protchenko O, Baratz E, Jadhav S, Li F, Shakoury-Elizeh M, Gavrilova O, Ghosh MC, Cox JE, Maschek JA, Tyurin VA,Tyurina YY, Bayir H, Aron AT, Chang CJ, Kagan VE, Philpott CC.Iron Chaperone Poly rC Binding Protein 1 Protects Mouse Liver From Lipid Peroxidation and Steatosis.Hepatology. 2021 Mar;73(3):1176-1193. doi: 10.1002/hep.31328.

Ugolini A, Tyurin VA,Tyurina YY, Tcyganov EN, Donthireddy L, Kagan VE, Gabrilovich DI, Veglia F.Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer.JCI Insight. 2020 Aug 6;5(15):e138581. doi: 10.1172/jci.insight.138581.

Wiernicki B, Dubois H,Tyurina YY, Hassannia B, Bayir H, Kagan VE, Vandenabeele P, Wullaert A, Vanden Berghe T.Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis.Cell Death Dis. 2020 Oct 27;11(10):922. doi: 10.1038/s41419-020-03118-0.

Anthonymuthu TS,Tyurina YY, Sun WY, Mikulska-Ruminska K, Shrivastava IH, Tyurin VA, Cinemre FB, Dar HH, VanDemark AP, Holman TR, Sadovsky Y, Stockwell BR, He RR, Bahar I, Bayir H, Kagan VE.Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis.Redox Biol. 2021 Jan;38:101744. doi: 10.1016/j.redox.2020.101744.

Huang LS, Kotha SR, Avasarala S, VanScoyk M, Winn RA, Pennathur A, Yashaswini PS, Bandela M, Salgia R,Tyurina YY, Kagan VE, Zhu X, Reddy SP, Sudhadevi T, Punathil-Kannan PK, Harijith A, Ramchandran R, Bikkavilli RK, Natarajan V.Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.J Biol Chem. 2020 Sep 18;295(38):13393-13406. doi: 10.1074/jbc.RA120.012680.

Olonisakin TF, Suber T, Gonzalez-Ferrer S, Xiong Z, Peñaloza HF, van der Geest R, Xiong Y, Osei-Hwedieh DO, Tejero J, Rosengart MR, Mars WM, Van Tyne D, Perlegas A, Brashears S, Kim-Shapiro DB, Gladwin MT, Bachman MA, Hod EA, St Croix C,Tyurina YY, Kagan VE, Mallampalli RK, Ray A, Ray P, Lee JS.Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation. J Clin Invest. 2021 Jan 4;131(1):e137468. doi: 10.1172/JCI137468.

Sparvero LJ, Tian H, Amoscato AA, Sun WY, Anthonymuthu TS,Tyurina YY, Kapralov O, Javadov S, He RR, Watkins SC, Winograd N, Kagan VE, Bayir H.Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS). Angew Chem Int Ed Engl. 2021 May 17;60(21):11784-11788. doi: 10.1002/anie.202102001.

Beatty A, Singh T,Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayir H, Kagan VE, Rennefahrt U, Peterson JR.Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244. doi: 10.1038/s41467-021-22471-y.

Sun WY, Tyurin VA, Mikulska-Ruminska K, Shrivastava IH, Anthonymuthu TS, Zhai YJ, Pan MH, Gong HB, Lu DH, Sun J, Duan WJ, Korolev S, Abramov AY, Angelova PR, Miller I, Beharier O, Mao GW, Dar HH, Kapralov AA, Amoscato AA, Hastings TG, Greenamyre TJ, Chu CT, Sadovsky Y, Bahar I, Bayir H,Tyurina YY, He RR, Kagan VE.Phospholipase iPLA2 averts ferroptosis by eliminating a redox lipid death signal. Nat Chem Biol. 2021 Apr;17(4):465-476. doi: 10.1038/s41589-020-00734-x.

Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A,Tyurina YY, Kagan VE, Wenzel SE.15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation. J Clin Invest. 2022 Jan 4;132(1):e151685. doi: 10.1172/JCI151685. PMID: 34762602, PMCID:PMC8718153.

Lamade AM, Wu L, Dar HH, Mentrup HL, Shrivastava IH, Epperly MW, St Croix CM,Tyurina YY, Anthonymuthu TS, Yang Q, Kapralov AA, Huang Z, Mao G, Amoscato AA, Hier ZE, Artyukhova MA, Shurin G, Rosenbaum JC, Gough PJ, Bertin J, VanDemark AP, Watkins SC, Mollen KP, Bahar I, Greenberger JS, Kagan VE, Whalen MJ, Bayir H.Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death. Redox Biol. 2022 Apr;50:102232. doi: 10.1016/j.redox.2022.102232. Epub 2022 Jan 10. PMID: 35101798 PMCID: PMC8804265.

Aguilera A, Berdun F, Bartoli C, Steelheart C, Alegre M, Bayir H,Tyurina YY, Kagan VE, Salerno G, Pagnussat G, Martin MV.C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria.J Cell Biol.2022 Feb 7;221(2):e201911005. doi: 10.1083/jcb.201911005. Epub 2021 Nov 24. PMID: 34817556, PMCID: PMC8624678.

Li W, Terada Y,Tyurina YY, Tyurin VA, Bery AI, Gauthier JM, Higashikubo R, Tong AY, Zhou D, Nunez-Santana F, Lecuona E, Hassan A, Hashimoto K, Scozzi D, Puri V, Nava RG, Krupnick AS, Lavine KJ, Gelman AE, Miller MJ, Kagan VE, Bharat A, Kreisel D.Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury.Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2111537119. doi: 10.1073/pnas.2111537119. Epub 2022 Mar 1. PMID: 35238643, PMCID: PMC8917381.

Dar HH, Epperly MW, Tyurin VA, Amoscato AA, Anthonymuthu TS, Souryavong AB, Kapralov AA, Shurin GV, Samovich SN, St Croix CM, Watkins SC, Wenzel SE, Mallampalli RK, Greenberger JS, Bayir H, Kagan VE,Tyurina YY.P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis. JCI Insight. 2022 Feb 22;7(4):e156013. doi: 10.1172/jci.insight.156013. PMID: 35041620, PMCID:PMC8876480.

Bednash JS, Kagan VE, Englert JA, Farkas D,Tyurina YY, Tyurin VA, Samovich SN, Farkas L, Elhance A, Johns F, Lee H, Cheng L, Majumdar A, Jones D, Mejia OR, Ruane-Foster M, Londino JD, Mallampalli RK, Robinson RT.Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.Transl Res. 2022 Feb;240:1-16. doi: 10.1016/j.trsl.2021.10.007. Epub 2021 Nov 2. PMID: 34740873, PMCID:PMC8562047.

Jang S, Chapa-Dubocq XR,Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA, Bayir H, Kagan VE, Javadov S.Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes.Redox Biol. 2021 Sep;45:102021. doi: 10.1016/j.redox.2021.102021. Epub 2021 Jun 1. PMID: 34102574, PMCID: PMC8187237.

Vats K, Kruglov O, Mizes A, Samovich SN, Amoscato AA, Tyurin VA,Tyurina YY, Kagan VE, Bunimovich YL.Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure.Redox Biol.2021 Nov;47:102143. doi: 10.1016/j.redox.2021.102143. Epub 2021 Sep 25. PMID: 34592565, PMCID:PMC8487085.

Department/Affiliation